Searching…
本研究关注于一些较为古老（现代人类和古人类分化之前）的deletion受到平衡选择的情况。和中性遗传漂变相比，现代人类中有更多的古老多态位点，这些位点很有可能 … 概览 人类基因组中，有数万的常见多态性位点和人类的疾病相关。不过一般认为，这些多态性位点对人类的适应性影响不大，在人群中以近乎中性的特质随机波动。只有一小部分位点能够影响人的适应性，在自然选择作用下，这些小部分位点通常以较低频率存 … 很多古老的多态位点受到平衡选择的作...
2001年10月1日 · For deletional bias to lead to the loss of genes and the corresponding DNA, selection on those genes must be ineffective owing to low selection coefficients or to small population size.
The level of bias toward deletions varies considerably among the prokaryotic genomes examined (fig. 1), allowing us to test two hypotheses concerning the role of deletional bias in genome evolution.
Thus, for short neutral sequences, an insertion bias is expected. Here, we develop a set of increasingly complex models of indel dynamics that incorporate border-induced selection.
The intrinsic bias toward DNA deletion (and hence gene loss) that characterizes mutational processes in prokaryotes (as well as eukaryotes) results in nonadaptive genome reduction (13), whereas selection …
2019年12月7日 · Unsurprisingly, a slight deletion bias (higher deletions probabilities) results in a slow decrease of average RBS size and may lead to their eventual vanishing. Contrary to intuition, strictly …
So, although genomes may indeed shrink by a slow process of deletion bias in small indels, they may also be expected to grow by a faster mechanism of insertion bias in large indels.
Quantitative assessment of DNA gain and loss through DSB repair processes suggests deletion-biased DSB repair causing ongoing genome shrinking in A. thaliana, whereas genome size in barley remains …
