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Welcome AL-Base is a curated database of antibody light chain sequences associated with diseases known as plasma cell dyscrasias (PCD), primarily immunoglobulin light chain amyloidosis, also known as AL amyloidosis. A...
AL-Base, a curated database of human immunoglobulin (Ig) light chain (LC) sequences derived from patients with AL amyloidosis and controls, is described, along with a collection of analytical and graphic tools designe...
Sep 11, 2024 · Results: AL-Base now contains 2,193 monoclonal light chain sequences from plasma cell dyscrasias. Sixteen germline precursor genes were enriched in AL amyloidosis, relative to multiple myeloma and the p...
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ALBase is designed to compile and analyze Ig LC sequences from patients with AL amyloidosis, to compare their predicted protein sequence and structure to non-amyloidogenic LC sequences from patients with multiple myel...
Dec 6, 2024 · Rarely-observed light chain variable genes may carry a high risk of AL amyloidosis. New approaches are needed to define sequence-associated risk factors for AL amyloidosis. AL-Base is a foundational reso...
Nov 2, 2023 · Blood-Based Diagnostic Assay for λ Light Chain Amyloidosis through Quantification of an Amyloidogenicity-Indicating Neo-Epitope
AL-Base is a project that collects and analyzes sequences of light chains involved in amyloidosis, a rare disease. It is a resource for researchers and clinicians to explore the diversity and patterns of light chain variants.
Jul 6, 2009 · AL-Base, a curated database of human immunoglobulin (Ig) light chain (LC) sequences derived from patients with AL amyloidosis and controls, is described, along with a collection of analytical and g...
Sep 15, 2024 · Background: Each monoclonal antibody light chain associated with AL amyloidosis has a unique sequence. Defining how these sequences lead to amyloid deposition could facilitate faster diagnosis and lead ...
