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SMARCA4 encodes a protein involved in chromatin remodeling, which is important for regulating the binding of transcription factors to DNA (also known as BRG1)
Practice question #1 The images above show SMARCA4 / BRG1 IHC for a 28 year old woman with a 10 cm mass of the uterine corpus. What is the most likely diagnosis? Dedifferentiated endometrial carcinoma High grade endom...
Comment: Immunohistochemical tests for SMARCA4 / BRG1 and SMARCA2 / BRM show loss of expression. Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) can be associated with the rhabdoid tumor predisposition ...
Ovary tumor - Granulosa cell tumor - juvenile is a sex cord stromal tumor composed of primitive appearing granulosa cells with follicular and solid growth patterns
Undifferentiated carcinomas of the ovary are characterized by a patternless, sheet-like growth of discohesive tumor cells with an aggressive clinical course.
Sinonasal undifferentiated carcinoma (SNUC) is an undifferentiated carcinoma lacking evidence of differentiation by histology and immunohistochemistry; diagnosis of exclusion
Esophagus - Undifferentiated carcinoma Esophageal undifferentiated carcinoma is a rare and aggressive carcinoma that is histologically characterized by sheets of cells with high grade features, frequent rhabdoid appea...
Rhabdoid tumor of the kidney is a highly malignant undifferentiated tumor composed of noncohesive cells with large, eccentric nuclei, prominent nucleoli and intracytoplasmic inclusions
Teratocarcinosarcoma (TCS) is a malignant sinonasal tract neoplasm containing mixed epithelial, mesenchymal and primitive neuroepithelial elements.
Mediastinum - Germ cell tumors account for 1 - 15% of all mediastinal neoplasms in adults and 11 - 20% in children and are classified as seminomas and nonseminomatous
