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The Cdkn2a gene was positionally identified as the regulator of IFNβ within Bbaa1, and determined to function through its protein product p19 alternative reading frame (p19ARF).
Jan 14, 2026 · Multiple Tumor Suppressor 1 3 4 CDKN2A/ARF Intron 2 LncRNA 2 3 Alternative Reading Frame 3 4 Inhibitor Of Cdk4 A 2 3 MTS-1 3 4 Cell Cycle Negative Regulator Beta 3 P19 Alternate Open Reading Frame 2 P14...
CDKN2A, also known as cyclin-dependent kinase inhibitor 2A, is a gene which in humans is located at chromosome 9, band p21.3. [5] It is ubiquitously expressed in many tissues and cell types. [6] The gene codes for two...
To determine whether such mutations disrupt p19 (ARF) function, Quelle et al. (1997) introduced naturally occurring missense mutations into mouse Ink4a exon 2 sequences and tested mutant p16 and p19 proteins for their...
Dec 1, 1998 · The p19 ARF transcript, an alternative spliced form of the CDKN2a gene, has recently been shown to inhibit, like the p16 INK4a protein, cell cycle progression, raising the possibility that it might const...
Mar 3, 1998 · Therefore, it seems plausible to hypothesize that BALB/cAn mice are carrying defective alleles of Cdkn2a (Pctr1) and that tumors arising in these mice are susceptible to somatic mutation that may further...
Gene Synonyms ARF, CDK4I, CDKN2, CMM2, INK4, INK4A, INK4a, MLM, MTS-1, MTS1, P14, P14ARF, P16, P16-INK4A, P16INK4, P16INK4A, P19, P19ARF, TP16, p14, p16, p16INK4a, p19, p19Arf
基因信息 ... 品系描述 该小鼠的flox区域为p19ARF及p16INK4a转录本公共区域的exon2。 应用领域:肿瘤相关研究*使用本品系发表的文献需注明: Cdkn2a-Flox(p16/p19-Flox) mice (Cat. NO. NM-CKO-200015) were purchased from Shanghai Model Organisms Center, Inc..
2023年研究证实 紫草提取物 等化合物可通过提升CDKN2A表达增强胶质瘤耐药性治疗效果，2024年 表观遗传学 研究显示该基因甲基化水平与衰老进程及代谢指标显著相关。
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