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Mar 18, 2021 · An atlas of PML/RARα direct targets redefines the activating function and explains synergism of all- trans retinoic acid/arsenic trioxide. PML/RARα activates target gene GFI1 through chromatin conformat...
Although acute promyelocytic leukemia (APL) is one of the most characterized forms of acute myeloid leukemia (AML), the molecular mechanisms involved in the development and progression of this disease are still a matt...
Feb 22, 2022 · Acute promyelocytic leukemia (APL) is driven by the oncoprotein PML/RARα, which destroys the architecture of PML nuclear bodies (NBs). PML NBs are critical to tumor suppression, and their ...
Jun 7, 2022 · PML::RARA is a fusion of 2 genes: PML, which encodes promyelocytic leukemia protein and RARA, which encodes retinoic acid receptor alpha
PML-RARα阳性的APL发病人群以青中年为主，平均发病年龄44岁 [12]，本研究中患者发病的中位年龄为40岁，与报道相符。 PML基因断裂点不同，产生了3种不同类型的PML-RARα融合基因。 本研究主要针对PML-RARα阳性APL不同亚型的临床特点、治疗反应以及预后等方面进行 ...
PML-RARA融合基因由15号染色体上的 PML基因 与17号染色体上的 RARA基因 （视黄酸受体α基因）发生断裂后重新连接形成。融合蛋白抑制正常造血细胞分化，导致骨髓中异常早幼粒细胞大量堆积。
What is PML RARA fusion protein?
