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Podocin is a protein component of the filtration slits of podocytes. Glomerular capillary endothelial cells, the glomerular basement membrane and the filtration slits function as the filtration barrier of the kidney g...
NPHS2（Podocin）是由位于人类1号染色体q25.2区域的NPHS2基因编码的膜整合蛋白，其外文名称为Podocin，Uniprot登记号为Q9NP85。该蛋白通过连接细胞膜与细胞骨架调节肾小球滤过屏障的通透性，并与nephrin等分子共同维持足细胞裂孔隔膜的结构完整性。NPHS2基因全长26kb，包含8个外显子，编码383个氨基酸组成的 ...
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Jan 15, 2026 · NPHS2 is a gene that encodes podocin, a protein involved in glomerular permeability regulation. Mutations in NPHS2 cause steroid-resistant nephrotic syndrome, a kidney disorder. Find gene information, p...
Podocin Podocin (NPHS2) is a kidney-specific member of the stomatin family of proteins. The NPHS2 gene was first identified as being mutated in patients with a familial idiopathic nephrotic syndrome (Boute et al., 200...
Abstract Podocytes are crucial cells of the glomerular filtration unit and plays a vital role at the interface of the blood-urine barrier. Podocyte slit-diaphragm is a modified tight junction that facilitates size and...
Analysis of podocin expression in patients with NPHS2 mutations offers an invaluable manner for defining anomalous dislocation in vivo suggesting functional anomalies.
