zhuanlan.zhihu.com
TfR1(CD71)靶向肿瘤治疗 - 知乎
背景介绍转铁蛋白受体1(TfR1)，又称分化簇71(CD71)，是一种与转铁蛋白(Tf)结合的II型跨膜糖蛋白，通过与铁结合的Tf相互作用，在细胞摄取铁的过程中发挥重要作用。铁是细胞多种生物过程所必需的，也是DNA合成和细胞…
TF1细胞CD71
Searching…
Web results
en.wikipedia.org
Transferrin receptor 1 - Wikipedia
Transferrin receptor protein 1 (TfR1), also known as C luster of D ifferentiation 71 (CD71), is a protein that in humans is encoded by the TFRC gene. [5][6] TfR1 is required for iron import from transferrin into cells...
www.frontiersin.org
Frontiers | Antibodies Targeting the Transferrin Receptor 1 ...
Mar 17, 2021 · The transferrin receptor 1 (TfR1), also known as cluster of differentiation 71 (CD71), is a type II transmembrane glycoprotein that binds transferrin (Tf) and performs a critical role in cellular iron u...
www.mdpi.com
Beyond Iron: The Roles of CD71 in the Pathophysiology of ...
Nov 21, 2025 · CD71, also known as transferrin receptor 1 (TfR1), is a transmembrane glycoprotein essential for cellular iron uptake, a prerequisite for cell proliferation, differentiation, and survival. While its can...
www.univ-bio.com
TfR1（CD71）导向的肿瘤治疗策略
Nov 15, 2024 · TfR1（CD71）导向的肿瘤治疗策略，乃是一种极具潜力的抗癌途径。其核心在于精准锁定 TfR1（CD71）这一特定靶点，凭借对该靶点独特生理特性与功能机制的深入洞察，设计并开发出针对性的治疗手段。通过特异性地作用于 TfR1（CD71），有望阻断肿瘤细胞的关键营养摄取通道或干扰其异常增殖信号传导 ...
pmc.ncbi.nlm.nih.gov
Transferrin receptor 1 is a cellular receptor for human heme ...
Abstract Iron is essential for living cells. Uptake of iron-loaded transferrin by the transferrin receptor 1 (CD71, TFR) is a major but not sufficient mechanism and an alternative iron-loaded ligand for CD71 has been ...
www.mabnus.cn
铁转蛋白受体CD71 - mabnus.cn
CD71是铁转蛋白受体1（TFRC），是细胞表面的主要铁摄取蛋白，铁的摄取是由转铁蛋白（Tf）-铁复合物的内化介导的，通过网格蛋白依赖性途径，受体介导的组成型内吞作用，以维持细胞内铁稳态。 CD71在许多肿瘤细胞中大量表达，它是一个潜在的肿瘤标志物。