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Dec 20, 2022 · Methods: The AVETUX trial aimed to combine the PD-L1 antibody avelumab with the standard of care chemotherapy combination FOLFOX and the anti-EGFR antibody cetuximab. Furthermore, we performed a central...
Feb 4, 2020 · Avelumab and cetuximab in combination with FOLFOX in patients with previously untreated metastatic colorectal cancer (MCRC): Final results of the phase II AVETUX trial (AIO-KRK-0216).
Sep 29, 2022 · AVETUX is a single arm multicentric phase II investigator initiated trial conducted by the Arbeitsgemeinschaft Internistische Onkologie (AIO) in 11 German sites in patients with previously untreated RAS...
文献「AVETUX試験の翻訳解析および最終有効性-転移性結腸直腸癌におけるアベルマブ,セツキシマブおよびFOLFOX【JST・京大機械翻訳】」の詳細情報です。J-GLOBAL 科学技術総合リンクセンターは、国立研究開発法人科学技術振興機構（JST）が運営する、無料で研究者、文献、特許などの科学技術 ...
Dec 20, 2022 · The AVETUX trial tested the combination of targeted antibodies, chemotherapy, and ICB, among others, to revoke the immunogenicity of MSS mCRC. We here report the final overall survival, central radiolog...
In summary, we report the final overall survival of the AVETUX trial and propose T cell clonality and diversity as a potential marker to predict response to chemo- immunotherapy combinations in ...
May 31, 2017 · Avelumab 和 Cetuximab 联合 FOLFOX 治疗既往未治疗的转移性结直肠癌患者 - II 期 AVETUX-结直肠癌 (CRC) 试验。 AVETUX 是一项单臂多中心 II 期研究者发起的试验，由 Arbeitsgemeinschaft Internistische Onkologie (AIO) 在德国的 11 个地点对先前未经治疗的 RAS / BRAF 野生型 mCRC 患者...
May 31, 2023 · Modified FOLFOXIRI plus cetuximab and avelumab as initial therapy in RAS wild-type unresectable metastatic colorectal cancer: Results of the phase II AVETRIC trial by GONO.
In mCRC, AVETUX, a single-arm multicentric phase II trial, evaluated the combination of cetuximab and avelumab with chemotherapy (FOLFOX) as first-line treatment in RAS/BRAF WT MSS or MSI mCRC patients (18).
2 研究方法 本研究纳入了符合要求的43例患者,AVETUX方案应用阿维鲁单抗、西妥昔单抗和含有奥沙利铂的改良FOLFOX6,进行了肿瘤突变分型的下一代基因面板测序、液体活检监测以及数字液滴PCR来确认个体突变。翻译分析包括组织免疫组化、多光谱成像和肿瘤浸润性T细胞的序列测序,检测到的PD-L1突变在 ...
