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2026年1月24日 · Our findings further validate CISH as a potent and druggable intracellular checkpoint capable of boosting anti-tumor T cell responses across diverse cancer types, independent of PD-L1 …
2026年1月14日 · Complete information for CISH gene (Protein Coding), Cytokine Inducible SH2 Containing Protein, including: function, proteins, disorders, pathways, orthologs, and expression.
CISH and IHC are different in that IHC measures protein expression whereas CISH measures DNA amplification. [13] This difference is particularly useful for HER-2/neu because it has been found that …
作者发现CISH缺失的iPSC衍生的NK细胞能够有效治愈具有人类 白血病细胞 的小鼠，而未经修饰的NK细胞治疗的小鼠则死于白血病。 这些研究表明，可以编辑iPSC衍生的NK细胞，以去除细胞内的抑制基 …
2022年5月19日 · We show that CISH does not only regulate interleukin-15 (IL-15) signaling pathways but also natural cytotoxicity receptors (NCR) pathways, triggering CISH protein expression.
CISH, or chromogenic in situ hybridization, is a process in which a labeled complementary DNA or RNA strand is used to localize a specific DNA or RNA sequence in a tissue specimen.
Hence, this study reveals a mechanism by which CISH promotes PD-1 expression by suppressing the expression of FBXO38 and proposes a new strategy for augmenting the therapeutic effect of CAR-T …
