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EM-523 has pED50 values of 8.19 and 6.08 for promoting contractions in rabbit small intestinal tissue and human duodenal tissue, respectively. EM-523 can be used in the research of gastrointestinal diseases. For resea...
Highly sensitive high-performance liquid chromatographic determination method for a new erythromycin derivative, EM523, and its major metabolites in human plasma and urine using post-column tris (2,2'-bipyridine) ruth...
Erythromycin A enol ether (EM523), a degradation product of Erythromycin A under acidic conditions, is an erythromycin analog with no antibacterial effect but is a potent motilin agonist .
Mar 18, 2026 · Here we show that systemically administered macrolide antibiotics and a non-antibiotic erythromycin derivative, EM-523, restore DEL-1 expression in 18-month-old ("aged") mice while promoting regeneratio...
EM-523 | C38H67NO12 | CID 9831800 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety/hazards/toxicity information, supplier lists, and more.
Methods: The prokinetic effect of EM523 on motor-stimulating activity in the stomach, duodenum, and jejunum in seventeen conscious dogs was studied using force transducers implanted long term.
We conclude that EM-523 is a potent motilin agonist. Erythromycin may stimulate gastrointestinal motor activity via its effect upon motilin receptors.
EM-523 and motilin induced contractions in the rabbit intestinal preparations but not in the rat or guinea pig preparations. In contrast, PGF2 alpha induced contractions in all three intestinal preparations. The rabbi...
Description EM-523 is a motilin agonist and an erythromycin derivative. EM-523 has pED50 values of 8.19 and 6.08 for promoting contractions in rabbit small intestinal tissue and human duodenal tissue, respectively. EM...
EM523, a motilide, was recently developed for clinical trials by Shimizu Pharmaceutical Co. of Japan as a completely new type of orally ingestable motilin ago-nist.
