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Interleukin-10 receptor (IL-10R) is a type II cytokine receptor. The receptor is tetrameric, composed of 2 α [1] and 2 β [2] subunits. The α subunit (encoded in the Il10ra gene) is expressed on haematopoietic cells (s...
Jun 23, 2023 · Circulating interleukin 10 (IL-10) binds as a homodimer to tetrameric IL-10 receptor (IL-10R) complex and induce the downstream activation of Janus kinase 1 (Jak1) and tyrosine kinase 2 (Tyk2) and the s...
Interleukin-10 (IL-10) and IL-10 Receptor (IL-10R) IL-10 is an important multifunctional cytokine, which has been found to be important in a variety of rheumatic and neoplastic diseases. Relative to autoimmunity, IL-1...
Mar 3, 2025 · IL-10R expression on tumor-infiltrating immune cells exhibits a hysteretic response to intratumor IL-10 concentration. Leveraging such a property, an engineered Salmonella enterica strain can reconcile t...
Nov 21, 2025 · IL-10–producing tolDC dampen B cell responses via T cell inhibition, offering a targeted strategy for specific B cell modulation.
IL-10 Receptor (IL-10R) Signaling IL-10 possess potent anti-inflammatory properties, repressing the expression of inflammatory cytokines such as TNF-Alpha, IL-6, and IL-1 by activated macrophages.
Explore the IL-10 signaling pathway and find antibodies to detect some of its target proteins, including CD14, IL-10, IL-1alpha, and IL-1beta.
IL-10 (Fiorentino et al., 1989; Moore et al., 1990) is the founding member of a family of cytokines that also includes IL-19, IL-20, IL-22, IL-24, IL-26, IL-28A, IL-28B, and IL-29 (reviewed in Ouyang and O’Garra, 2019...
Apr 3, 2025 · Analysis of human samples suggests that the IL-10R hi state might be a ubiquitous trait across human tumor types. Our study unveils the unsolved mechanism behind bacterial immunotherapy’s dual challenge ...
A Mendelian predisposition to B-cell lymphoma caused by IL-10R deficiency. Blood 2013, 122, 3713–22. doi: 10.1182/blood-2013-06-508267. [DOI] [PubMed] [Google Scholar] 12. Shah N, Kammermeier J, Elawad M, Glocker EO.....
