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References Curated Citations NCI-Navy Medical Oncology Branch Cell Line Supplement. J. Cell. Biochem. suppl. 24: 1996. Sordella R, et al. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pat...
$id in Cellosaurus, a cell line database, cell line catalogue, cell line ontology
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因此， 同时靶向MET及EGFR成为了解决EGFR患者耐药的潜在方案。 近期，药明康德肿瘤和免疫部在原本对EGFR抑制剂相对敏感的NCI-H1975肺癌细胞系上，以慢病毒过表达的方式构建出NCI-H1975-HGF稳定细胞株，为EGFR和MET抑制剂的相关研究提供模型。
The NCI-H1975 cell line is a well-established model derived from human non-small cell lung carcinoma (NSCLC), specifically adenocarcinoma. This cell line is particularly significant due to its dual mutations in the ep...
EGFR, the epidermal growth factor receptor, is a cell-surface receptor tyrosine kinase, and activated by binding of its specific ligand, such as epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha).
Human EGFR-T790M/C797S/L858R Stable Cell Line - NCI-H1975 is a unique form of cell line genetically engineered to express three specific mutations in the epidermal growth factor receptor (EGFR) gene.
