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The major focus of this review is to highlight some of the controversies surrounding the paradoxical role of the PMCA in cell death and survival, challenging the conventional view of ATP-dependent regulation of the PM...
Aug 20, 2025 · Structural insights into ultrafast Ca2+ transport by plasma membrane Ca2+-ATPases are provided, highlighting an essential role for PtdIns(4,5)P2 dynamics.
Rendered image of the Ca 2+ pump The plasma membrane Ca2+ ATPase (PMCA) is a transport protein in the plasma membrane of cells that functions as a calcium pump to remove calcium (Ca 2+) from the cell. PMCA function is...
Aug 26, 2021 · The Plasma Membrane Ca2+ pumps (PMCA) are P-ATPases that control Ca2+ signaling and homeostasis by transporting Ca2+ out of the eukaryotic cell. Humans have ...
The amplitude and duration of Ca 2+ signaling is crucial for B-cell development and self-tolerance; however, the mechanisms for terminating Ca 2+ signals in B cells have not been determined. In lymphocytes, plasma mem...
Jan 1, 2018 · The major focus of this review is to highlight some of the controversies surrounding the paradoxical role of the PMCA in cell death and survival, challenging the conventional view of ATP-dependent regula...
The presence of an ATP-dependent Ca 2+ transporter located in the plasma membrane was first identified in erythrocytes half a century ago (327). The plasma membrane calcium ATPase (PMCA) has since been classified as a...
