www.zhihu.com
pmel-1 T 细胞是什么？ - 知乎
这个小鼠是携带pmel-1基因重排的T细胞受体的转基因小鼠。 pmel-1这个基因特异于人SILV（gp100）的小鼠同源物（pmel-17），是一种由大多数恶性黑素瘤细胞（包括B16黑素瘤）以及正常黑色素细胞表达的参与色素合成的酶。
pmel1t细胞
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www.jax.org
005023 - pmel-1 Strain Details
This transgenic strain carries a rearranged T cell receptor transgene specific for the mouse homologue (pmelSi or pmel-17) of human premelanosome protein (referred to as PMEL, SILV or gp100), and the T lymphocyte spec...
pubmed.ncbi.nlm.nih.gov
Adoptive CD8+ T cell therapy generates immunological memory to inhibit ...
Adoptive T cell therapy has emerged as a promising treatment for cancer. However, it is unknown whether adoptively transferred anti-tumor T cells can form immunological memory and provide continuous protection against...
www.nature.com
Different tumour-resident memory T-cell subsets regulate ... - Nature
The involvement of tumour-resident memory T (TRM) cells in responses to immune checkpoint inhibitors remains unclear. Here, we show that while CD103+CD8 TRM cells are involved in response to PD-1 ...
www.sohu.com
「精品导读」过继性T细胞疗法与免疫逃逸_pmel- - 搜狐
在开始这篇文章的学习之前，我们最开始要搞清楚的一个问题就是： 什么是过继性免疫细胞疗法？ 过继性免疫治疗（ACT），是指从肿瘤患者体内分离免疫活性细胞，在体外进行扩增和功能鉴定，然后向患者回输，从而达到直接杀伤肿瘤或激发机体免疫应答杀伤肿瘤细胞的目的。 随着ACT疗法的迅猛 ...
www.bafang.org.cn
Pmel基因的功能与作用机制解析 - 八方基因
PMEL基因概述 PMEL基因，也称为premelanosome protein，位于人类染色体12q13.2位置。这个基因编码的蛋白在黑色素细胞中起着至关重要的作用，特别是在黑色素的合成和储存过程中。PMEL蛋白，也被称为Pmel17或gp100，是黑色素小体的主要成分，这些小体是存储黑色素的细胞器。
news.sjtu.edu.cn
上海交大李丹课题组揭示PMEL组装聚集形成黑色素体的全新机制_交大智慧_上海交通大学新闻学术网
黑色素体（melanosome）是决定皮肤、毛发和眼睛颜色的关键细胞器。其生物发生和功能失衡导致多种遗传性低色素综合征、黑色素瘤及相关系统性疾病。研究人员早期就注意到其内部存在规则的片层状结构，但这些片层如何由黑色素体结构蛋白 PMEL 组装而成、在原位呈现何种三维构型，一直缺乏原子 ...
www.researchgate.net
Kinetics of the expansion of pmel-1 T cells in B16 tumor treatment ...
Download scientific diagram | Kinetics of the expansion of pmel-1T cells in B16 tumor treatment model. A, tumor regression by adoptively transfer pmel-1T cells. Points, mean of measurements from ...
journals.plos.org
Identification of the Genomic Insertion Site of Pmel-1 TCR α ... - PLOS
The pmel-1T cell receptor transgenic mouse has been extensively employed as an ideal model system to study the mechanisms of tumor immunology, CD8+ T cell differentiation, autoimmunity and adoptive immunotherapy. The ...
www.protocols.io
In vitro pmel-1 T cell-mediated cytotoxicity assay with CytoTox-ONE ...
A plate-based assay to estimate the cytotoxic activity of pmel-1T cells against target cancer cells. The CytoTox-ONE Homogeneous Membrane Integrity Assay from Promega (Madison,...