SOCS3 - 维基百科,自由的百科全书
"Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain".
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"Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain".
After 20 years of extensive research, SOCS3 has emerged as arguably the most important family member, through its regulation of both cytokine- and pathogen-induced cascades. In fact, low expression of SOCS3 is associa...
Jan 15, 2026 · Complete information for SOCS3 gene (Protein Coding), Suppressor Of Cytokine Signaling 3, including: function, proteins, disorders, pathways, orthologs, and expression.
Dec 19, 2024 · 本文详细介绍了SOCS3基因的功能、作用机制、信号通路及其与疾病的关系,帮助读者全面理解这一重要基因在细胞信号传导中的角色。 SOCS3基因简介 SOCS3,全名suppressor of cytokine signaling 3 ,是一个位于17号染色体长臂(17q25.3)的基因。
SOCS3 (Suppressor of Cytokine Signaling 3,细胞因子信号转导抑制因子 3)是 SOCS 家族中最重要的负反馈调节蛋白之一。 它主要通过抑制 JAK-STAT 通路 来调控细胞对细胞因子的响应。
该家族包含SOCS1-7及CIS共8种成员,其蛋白结构由N区、SH2结构域和SOCS盒区构成,通过抑制JAK激酶或STAT转录因子的磷酸化作用负向调节JAK/STAT信号通路。
Jun 21, 2024 · SOCS1 and SOCS3 are the most well-characterized SOCS members in skin inflammatory diseases, where their inhibitory activity on cytokine activated JAKs and consequent anti-inflammatory action has been wi...
Sep 8, 2015 · Suppressor of cytokine signaling 3 (SOCS3) is a negative regulator of Janus protein kinase (JAK)/signal transducer and activator of transcription 3 (STAT3) pathway and may involve in the phosphorylation ...
该基因的表达由多种细胞因子诱导,包括 IL6、IL10 和干扰素 (IFN) -γ。 该基因编码的蛋白可与 JAK2 激酶结合,抑制 JAK2 激酶的活性。 对该基因的小鼠对应物的研究表明该基因在胎儿肝脏造血和胎盘发育的负调节中的作用。 [RefSeq 提供,2008 年 7 月]
SOCS3参与调节免疫反应、炎症过程以及代谢过程,对于维持机体免疫平衡和抑制肿瘤生长具有重要作用。 SOCS3的异常表达与多种疾病相关,包括肿瘤、自身免疫性疾病和代谢性疾病。