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Swainsonine is a natural product that inhibits glycoside hydrolases and has immunomodulatory and chemotherapeutic effects. It is also a poisonous compound found in some plants and fungi, especially in locoweed, which ...
Aug 11, 2025 · (−)-Swainsonine is a polyhydroxylated indolizidine alkaloid with potent inhibitory activity against α- d -mannosidases. Although the genetic basis of its biosynthesis has been established, the...
Swainsonine causes a variety of neurological disorders, including locoism and "slobbers syndrome" in livestock. In man it causes a lysosomal storage disease, biochemically and morphologically similar to mannosidosis.
Swainsonine is a synthetic salt form of a plant toxin derived from a plant called locoweed. It is a competitive inhibitor of Golgi α-mannosidase II and affects the structure of carbohydrates, which can inhibit metasta...
5 days ago · Discover what is the use of Swainsonine, a potent alpha-mannosidase inhibitor. Explore its applications in cancer research, immunomodulation, and its toxic effects from locoweed.
Sep 27, 2024 · Abstract (-)-Swainsonine is a polyhydroxylated indolizidine alkaloid with potent inhibitory activity against alpha-D-mannosidases. In this work, we successfully reconstituted swainsonine biosynthetic pa...
Swainsonine, an indolizidine alkaloid, inhibits the processing of asparagine-linked glycoproteins in both cell-free extracts and animal cells in culture.
