thrope ingold效应

Thorpe–Ingold effect - Wikipedia

偕二甲基效应_百度百科

偕二甲基效应，又称Thorpe-Ingold效应，由Richard M. Beesley、Christopher K. Ingold与Jocelyn F. Thorpe于20世纪初发现，指有机物中亚甲基碳连接两个甲基时，空间排斥导致键角变化：内键角变小，邻近基团空间接近从而加速环化反应。

偕二甲基效应 Thorpe-Ingold Effect | 化学空间 Chem-Station

偕二甲基效应，又称Thorpe-Ingold 效应。 当一个亚甲基上的氢被两个甲基取代后就形成了一个偕二甲基碳。两个甲基相互推搡的结果是增大了两者之间的键角，同时缩小了构成碳四面体的另一对键的键角，于是相连基团之间就被推得近了一点。这个微小的键角变化显著地影响了成环反应的熵变，使得有偕二甲基的分子链易于成环（维基百科）。

实用有机合成化学 | 百公斤量级构建偕二甲基环丙烷，知名药企也在用 -...

偕二甲基（ gem-dimethyl）是指同一碳原子上取代的两个甲基。 提到该片段，大家或许会想到Thorpe-Ingold效应。 早在上世纪初，英国帝国理工学院（Imperial College London）的Richard M. Beesley、Christopher K. In…

Thorpe–Ingold effect | Opinion | Chemistry World

Continuing the work begun by Beesley, Ingold’s first paper with Thorpe soon followed. They proposed that two sterically demanding substituents would move apart, beyond the ideal tetrahedral ...

(PDF) Thorpe-Ingold Effect and Its Application in ...

Sep 15, 2014 · The Thorpe-Ingold effect can promote intra- and intermolecular cyclizations effectively, accelerating reaction rates and improving yields in cyclizations.

Utilization of the Thorpe–Ingold Effect in the Synthesis of ...

In addition to taking advantage of the Thorpe–Ingold effect through the use of gem -dialkyl-substituted cyclooctanoid systems, we have also preliminarily explored the use of analogous gem -dimethoxy derivatives.