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Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 (TIM-3) gene.
Nov 1, 2019 · T cell immunoglobulin and mucin domain-containing protein 3 (TIM3), a member of the TIM family, was originally identified as a receptor expressed on interferon-γ-producing CD4+ and CD8+ T cells.
Sep 23, 2025 · TIM3 is a coregulatory receptor that is highly abundant on multiple immune cell types, including T cells in response to prolonged exposure to antigen, and it marks functionally suppressed cytotoxic T ly...
Feb 13, 2024 · Here, we discuss the distinct functions of LAG-3, TIM-3, and TIGIT, including their contributions to the regulation of immune cells beyond T cells, their roles in disease, and the implications for their...
In this work, we summarized clinical trials incorporating TIM-3 targeting monoclonal and bispecific antibodies in monotherapy and combination therapy and highlighted the emerging role of cell-based therapies. Keywords...
Apr 9, 2025 · Our findings reveal that TIM-3 mediates microglia homeostasis through TGFβ signalling and highlight the therapeutic potential of targeting microglial TIM-3 in Alzheimer’s disease.
In this review, we summarize the role of TIM-3 in different diseases and its possible signaling pathway mechanisms, providing new insights for better breakthrough immunotherapy. Keywords: Autoimmune diseases; Gal-9; T...
Mar 8, 2024 · TIM-3 is a type I transmembrane protein with an extracellular domain consisting of an immunoglobulin variable (IgV)–like domain and a mucin domain, followed by a transmembrane domain and a cytoplasmic tail.
Jun 9, 2021 · Here, using conditional knockouts of TIM-3 together with single-cell RNA sequencing, we demonstrate the singular importance of TIM-3 on dendritic cells (DCs), whereby loss of TIM-3 on...
Jul 10, 2025 · TIM3 is highly upregulated in micrometastases, promoting survival, stemness, and immune escape. TIM3 + tumor cells are specifically selected during early seeding of micrometastasis.
