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Jan 15, 2026 · Complete information for TRIOBP gene (Protein Coding), TRIO And F-Actin Binding Protein, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium
TRIO and F-actin-binding protein is a protein that in humans is encoded by the TRIOBP gene. [5][6][7][8] This gene encodes a protein that interacts with Trio, which is involved with neural tissue development and in co...
Nov 17, 2021 · TRIOBP -1 consists of a pleckstrin homology (PH) domain near the N-terminal and coiled coil (CC) domains that make up the C-terminal half of the protein. TRIOBP -1 is widely expressed and binds to F-act...
Learn about the TRIOBP gene, its function, mutations, and associated disorders. Explore research on TRIOBP and its potential role in health and disease.
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Oct 27, 2020 · The TRIOBP (TRIO and F-actin Binding Protein) gene encodes multiple proteins, which together play crucial roles in modulating the assembly of the actin cytoskeleton. Splicing of the TRIOBP gene is compl...
In seven families, six different mutant alleles of TRIOBP on chromosome 22q13 cosegregate with autosomal recessive nonsyndromic deafness. These alleles include four nonsense (Q297X, R788X, R1068X, and R1117X) and two ...
Jun 11, 2018 · The C-terminus of TRIOBP-5, corresponding to coiled-coil domain of TRIOBP-1, is localized at rootlets [9]. Exon 6 of TRIOBP-4/5 encodes several copies of two repeated motifs, R1 and R2; only the R1 moti...
Jun 11, 2018 · TRIO and F-actin-binding protein (TRIOBP) also referred to as Tara, was originally isolated as a cytoskeleton remodeling protein. TRIOBP-1 is important for regulating F-actin filament reorganization. TR...
Sep 15, 2024 · Autosomal recessive non-syndromic deafness-28 (DFNB28; OMIM #609823) specifically refers to prelingual sensorineural hearing loss (SNHL) resulting from homozygous or compound heterozygous mutations in t...
