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Uric acid - Wikipedia
Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C 5 H 4 N 4 O 3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a pro...
medlineplus.gov
Uric acid - blood : MedlinePlus Medical Encyclopedia
Apr 1, 2025 · Uric acid is a chemical created when the body breaks down substances called purines. Purines are normally produced in the body and are also found in some foods and drinks. Foods with a high content of
www.nature.com
Mechanisms of urate transport and uricosuric drugs inhibition ...
Feb 10, 2025 · URAT1 reabsorbs urate in kidney and is a drug target for gout. Here, authors report the structures of human URAT1 in complex with substrate urate or inhibitors benzbromarone and verinurad to ...
pmc.ncbi.nlm.nih.gov
Urate Handling in the Human Body - PMC
Low-dose aspirin also causes a decrease in renal clearance of urate. Salicylic acid, the active metabolite of aspirin, stimulates URAT activity [53]. Uricosuric Drugs FDA-approved drugs for the treatment of hyperurice...
www.sciencedirect.com
Uric acid in health and disease: From physiological functions ...
Apr 1, 2024 · At the apical membrane, influx transporters, including urate transporter (URAT) 1 (Enomoto et al., 2002; Lu, Nakanishi, Fukazawa, & Tamai, 2014; Nakanishi, Ohya, Shimada, Anzai, & Tamai, 2013; Sato et al...
journals.physiology.org
Molecular Physiology of Urate Transport
The specific transporter that mediates the uptake of urate into the vascular smooth muscle cell is not known, although the possibility that it is URAT-1 has been supported by the recent demonstration that both human a...
www.uptodate.com
Urate balance - UpToDate
Mar 4, 2026 · INTRODUCTION Urate balance in the body depends both on its production, which is driven by purine metabolism, and its disposal, which primarily occurs through the gastrointestinal tract and kidneys. Most ...