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Sep 1, 2023 · Sestrin2 plays an important role in cellular and mitochondrial homeostasis by regulating oxidative stress. In this study, we aimed to investigate whether recombinant adenovirus containing sestrin2 (RS) c...
Mar 8, 2023 · The AKI surgery performed in this study significantly increased PCr levels, especially in the aged mice, compared to the sham (Figure 2 A). Moreover, metformin was able to significantly reduce PCr levels...
Feb 25, 2023 · Sestrin2 (SESN2), a highly conserved stress-responsive protein, can be triggered by various noxious stimuli, such as hypoxia, DNA damage, oxidative stress, endoplasmic reticulum (ER) stress, and...
3 days ago · 目的如何防治围手术期常发生的急性肾损伤(acute kidney injury，AKI)一直是临床实践关注的核心。本研究旨在探讨应激诱导蛋白2(sestrin2，SESN2)在铁死亡诱导剂Erastin诱导的肾小管细胞铁死亡和ICR小鼠AKI中的作用及机制。方法体外试验方面，采用稳定转染慢病毒的人肾皮质近曲小管上皮细胞HK-2，分为体外 ...
Sestrin2 (SESN2), a highly conserved stress-inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative s...
Dec 4, 2019 · Sestrin2, as a negative feedback regulator of mTOR, provides neuroprotection by activation AMPK phosphorylation in neonatal hypoxic-ischemic encephalopathy in rat pups.
Mar 8, 2023 · The results indicate that metformin could significantly rescue AKI-induced cardiac dysfunction and injury via Sesn2 through an improvement in systolic and diastolic function, fibrotic and cellular damage...
